Axially substituted silicon phthalocyanine, method for synthesizing same and application of axially substituted silicon phthalocyanine to photodynamic therapy

The invention discloses novel axially substituted silicon phthalocyanine, a method for preparing the same and application of the axially substituted silicon phthalocyanine to photodynamic therapy. The axially substituted silicon phthalocyanine is a 4-piperidine methoxy axially substituted silicon phthalocyanine derivative. The method includes adding silicon phthalocyanine dichloride, 4-piperidinemethanol and alkaline catalysts into organic solvents in a reactor with a reflux device in nitrogen atmosphere, and carrying out heating reflux reaction to obtain the 4-piperidine methoxy substituted silicon phthalocyanine. The novel axially substituted silicon phthalocyanine, the method and the application have the advantages that the axially substituted silicon phthalocyanine structurally contains 4-piperidine methoxy, synergistic effects can be realized by the axially substituted silicon phthalocyanine which is used as a photosensitizer during photodynamic therapy, the method for synthesizing the novel axially substituted silicon phthalocyanine is simple, and the problem of easiness in aggregation of phthalocyanine in physiological environments can be solved (owing to the low aggregation degree of the axially substituted silicon phthalocyanine); the axially substituted silicon phthalocyanine is good in photostability, is high in absorption in phototherapy windows (with the sizes of 600-900 nm), is high in singlet oxygen quantum yield and has PDT (photodynamic therapy) application potential.