Cytotoxic Active Metabolites from Endophytic Fungus S15 from Hainan Plum-Yew (Cephalotaxus hainanensis)

Secondary metabolites from the endophytic fungus S15 from Hainan plum-yew (Cephalotaxus hainanensis Li) were studied. Two constituents were isolated and purified by multiple column chromatography, and their structures were identified as acetyl cytochalasin D (1) and cytochalasin D (2) by physicochemical and spectroscopic data. Both of the cytochalasins showed strong cytotoxic activity on tumor cell line SGC-7901 after bio-activity tests.