Long-term survival comparison of stereotactic radiotherapy versus surgery for elderly patients with clinical stage T1-T2 non-small cell lung cancer.

8511Background: There are several matched-paired analysis reports of comparing the long-term outcome between Stereotactic Body Radiation Therapy (SBRT) and surgical resection. Most of them are small series. This study aimed to compare the long-term overall survival (OS) after SBRT and surgery from a single medical center with surgery performed with the same group of surgeons. Methods: We used our cancer registry of 2005-2015. Patients with clinical staged T1 and T2 N0 diseases treated with either primary surgery or SBRT . Only patients elder than 65 years. The log rank p-value was used for overall survival comparison between the groups. Cox regression was used for univariate test for age, gender, race, smoking history, alcohol use, primary site location, laterality, T stage, and histology grade. Variables with p < 0.05 from univariate analysis were then used for propensity score based matching to compare the effect of surgery or SBRT on overall survival. Results: A total 1244 patients with clinically stag...