Co-prescribing of linezolid and serotonergic agents in a general hospital setting

Background Co-prescription of linezolid and serotonergic agents (SSRIs, SNRIs, NaSSA, TCAs) can lead to serotonin syndrome, this study seeks to identify prescribing practise of these agents. Methods Study of all general hospital inpatients prescribed intravenous linezolid in a 3-month period, using drug charts and clinical notes. Results Co-prescription occurred in 20% with SSRIs most frequently concurrently used. There were no cases of serotonin syndrome. There was no evidence in clinical notes of vigilance for potential interaction. Conclusion Co-prescription is common; awareness of potentially serious interaction is not evident in current practice.