Abstract 17507: Simulation of Transcatheter Aortic Valve Replacement and Assessment of Regurgitation in in-vitro Pulsatile Model With Patient-specific Anatomy

Introduction: Aortic regurgitation (AR) following transcatheter aortic valve replacement (TAVR) has been shown to be associated with increased mortality. However, regurgitant volume cannot be directly measured in clinical situation. We developed an in-vitro pulsatile circuit with patient-specific anatomical models for simulating the whole TAVR procedure and investigated the valve function depending on the hemodynamic conditions. Methods: Five patients with severe degenerative aortic valve stenosis (AS), who were treated with a 23mm SAPIEN XT and had AR after TAVR, were selected for modeling. The entire aortic valve complex, thoracic aorta, and iliofemoral artery of each patient were created by using the gated CT DICOM data, the 3D printing technology, and the dipping technique with elastic materials. Calcification deposition around the annulus was replicated by mimicking elasticity. Each model was incorporated into pulsatile flow circuit. Then a 23 mm SAPEN XT was implanted via transfemoral access in the ...