A retrospective study of effect of thyroid disorders on obstetric and perinatal outcomes: A hospital based study

Aims and Objectives: The study was undertaken in pregnant women to understand and analyze the obstetric and fetal outcomes of thyroid disorders. Materials and Methods: TSH estimation was used as universal screening in their first visit to our hospital. Those patients with abnormal TSH values, i.e. above 2.5mIU/ml in first trimester and above 3mIU/ml in second and third trimesters were evaluated for freeT3, freeT4 and TPO Abs. They were treated accordingly and dosage adjustments made and the tests repeated once in 4-6 weeks. They were followed throughout pregnancy and delivery. Results: Total no of pregnant women screened were 860, of which 130 had abnormal thyroid functions, thereby the prevalence of thyroid dis­orders being 15.11%. Of the 130 patients with thyroid disorders, 126 were hypothyroid and 4 were hyperthyroid. Among the 126 hypothy­roid cases, 48 were known cases and 78 were new cases. The total cases of subclinical hypothyroidism were 91, prevalence being 10.58% and overt cases were 35, prevalence being 4.06%; 4 cases were overt hyperthyroid, prevalence being 0.4%. 60.3% of subclinical hypothy­roidism were TPO positive and 39.6% of overt hypothyroidism were TPO positive (p value-