Method for preparing active material nanoparticles using lipid as lubricant for milling

The present invention relates to a method for preparing active material nanoparticles using a lipid as a lubricant for milling and, more specifically, to a method for preparing an active material as nanoparticles that may be used usefully in medicine, cosmetics, and functional food, by milling, with a roll mill, a mixture comprising an active material and a lipid as a lubricant, and a biocompatible polymer having a glass transition temperature of no less than 80℃, then removing the lipid used as a lubricant using a supercritical fluid.