Fast and Simple Method for Determination of Sumatriptan Succinate Based on a Mesoporous Material

A type of mesoporous carbon is synthesized in this work and its structural properties were characterized by nitrogen physisorption isotherms and Raman spectroscopy. Because of the large surface area and high crystallinity of the prepared material, we used it to modify the glassy carbon (GC) electrode. The obtained modified electrode (CMK-3/GCE) was successfully applied for simple and rapid determination of Sumatriptan succinate(Sum)in standard solutions and pharmaceutical tablets by using differential pulse voltammetry (DPV) method. The modified electrode displayed a decrease in the over potential and an obvious increase in the peak current compared with the bare glassy carbon electrode. The study of experimental parameters showed that the oxidation reaction is totally irreversible and maximum current response was obtained at pH=5 in 0.05 phosphate buffer. Under the optimum experimental conditions, Sum could be linearly detected in the wide concentration range of 1.50 µM-120 µM. The detection limit was down to around 0.8 µM (S/N=3). Since the prepared modified electrode exhibits a very good resolution between the DPV peaks of Sumatriptan, Paracetamol and Ascorbic acid, it can be applied for simultaneous detection of Sumatriptan in the presence of these compounds in pharmaceutical preparations.