Facilitation of evoked transcallosal responses by nootropic agents

: The effect of nootropic drugs was investigated by studying their influences on transcallosal responses in rats. Piracetam, meclofenoxate, vinpocetin, pyritinol, orotic acid and dihydroergotoxine as well as its components dihydroergocornine and dihydroergocrytpine enhance in a dose dependent manner the amplitudes of transcallosal responses. The evoked potentials remain unchanged after dihydroergocristine and nicergoline by the dosage used.