FORMULATION AND EVALUATION OF TASTE MASKED ORAL DISPERSIBLE TABLETS OF DOMPERIDONE USING SUBLIMATION METHOD

Difficulty in swallowing (dysphagia) is common among all age groups, especially for geriatric and pediatric patients. Oral dispersible tablets (ODT) constitute an innovative dosage form that overcome the problems of swallowing and provides a quick onset of action. The aim of the present research was to prepare taste masked oral dispersible tablets by sublimation method and investigate the effects of super disintegrant (Kollidon CL) on the disintegration time as well as the percent release of a model drug from Kollidon 30, Ispaghula husk and Guar Gum based formulations. Domperidone, an anti-emetic drug was taken as the model drug for the study. A high porosity was achieved using camphor as volatilizing agent which allowed easy penetration of dissolution media followed by rapid release of drug. The granules and tablets were evaluated and found to be acceptable according to standard limits. In vitro release studies were performed using USP apparatus-II (paddle method) in 900ml of 0.1N HCl (pH 1.2) at 50rpm. The release mechanisms were explored and explained with different kinetic model. Kollidon CL was found to cause a rapid disintegration of ODTs within 24 to 39 seconds. The highest drug release was obtained from F-6 (88.19%) containing Ispaghula husk. Finally, the overall study indicate a proper balance between the rate retarding polymers and disintegrant having a drug release profile of ODT under the presence of a volatilizing agent showed an acceptable disintegration time with a percent of drug release.