Bis(4-fluorophenyl)methyl(1H-1,2,4-triazol-1-yl-methyl)germane, a Germanium Analogue of the Agricultural Fungicide Flusilazole: Synthesis and Biological Properties.

Bis(4-fluorophenyl)methyl(1H-1,2,4-triazol-1-yl-methyl)germane (2), a germanium analogue of the agricultural fungicide flusilazole (1), has been synthesized from Cl 3 GeCH 2 Cl (3) by both a three-step and a four-step synthesis (3→(p-F-C 6 H 4 ) 2 Ge(CH 2 Cl)Br (4)→(p-F-C 6 H 4 ) 2 Ge(CH 2 Cl)CH 3 (5)→2; 5→(p-F-C 6 H 4 ) 2 Ge(CH 2 I)CH 3 (6)→2). The fungicidal properties of 2 have been compared with those of the parent silicon compound 1(studies on Si/Ge bioisosterism)