Comparative analysis of metabolites of Candida albicans and other clinically important fungi using gas chromatography

: Qualitative and quantitative compositions of metabolites of the fungi belonging to the genera Candida, Cryptococcus, Geotrichum, Aspergillus, Penicillium, Fusarlum, Actinomyces, Sporotrichum and Alternaria were studied. It was shown that the composition of carbohydrates, alcohols, volatile and nonvolatile fatty acids and amines after the fungi cultivation was specific of every genus. The in vitro investigation of the entire spectra of the metabolites such as monosugars, alcohols, volatile and nonvolatile acids and amines for the determination of the markers specific of the genus Candida demonstrated that for the indication of C. albicans the informative components were arabinitole (sugar alcohol), ethyl and isoamyl alcohols and nonvolatile fatty acids (fumaric, amber, oxalacetic and pyruvic). For the diagnosis of candidiasis it is advisable to determine D-arabinitole in biological fluids as a marker of Candida infection.