A morphometric analysis of tissue homeostasis in peptic ulcer patients during treatment with antihistamine preparations

: The authors carried out a comparative examination of 68 patients with duodenal ulcer receiving monotherapy with cithemidine and a combination of cithemidine and dimedrol. Clinical data indicate that combined use of H1- and H2-histamine blockaders produce a reliable therapeutic effect. Morphological investigations of biopsies from the periulcerous region and morphometry of cellular and noncellular structures showed that the mechanism of this effect consists in strengthening of the mast cell apparatus adding the excess of tissue histamine.