Euphoractone, a cytotoxic meroterpenoid with an unusual ent-abietane-phloroglucinol skeleton, from Euphorbia fischeriana Steud

ABSTRACT A novel meroterpenoid, euphoractone (1), was isolated from the extracts of the roots of Euphorbia fischeriana Steud. Its structure was determined by spectroscopic methods and X-ray crystallography. 1 possesses an unusual ent-abietane-phloroglucinol skeleton. The plausible biosynthetic pathway for 1 was proposed. 1 showed inhibitory activities against human lung cancer H23 and H460 cells with the IC50 values of 21.07 ± 3.54 and 20.91 ± 4.07 μmol/L.