Evaluation of a new biotin-DOTA conjugate for pretargeted antibody-guided radioimmunotherapy (PAGRIT®)

Nicoletta Urbano,Stefano Papi,Mauro Ginanneschi,Rita De Santis,Silvia Pace,Ragnar Lindstedt,Liliana Ferrari,SunJu Choi,Giovanni Paganelli,Marco Chinol

Evaluation of a new biotin-DOTA conjugate for pretargeted antibody-guided radioimmunotherapy (PAGRIT®)

2007

Nicoletta Urbano
Stefano Papi
Mauro Ginanneschi
Rita De Santis
Silvia Pace
Ragnar Lindstedt
Liliana Ferrari
SunJu Choi
Giovanni Paganelli
Marco Chinol

Purpose A novel biotin-DOTA conjugate (r-BHD: reduced biotinamidohexylamine-DOTA) was investigated in order to provide an efficient pretargeted antibody-guided radioimmunotherapy (PAGRIT®) application. Preclinical and clinical results are described.

Keywords:

Antibody
Biotin
Radiology
Medicine
Conjugate
DOTA
Animal model
Radioimmunotherapy
Specific activity
Immunology
Molecular biology
Nuclear medicine
Pretargeting
tumour therapy

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