Изменения ионных токов нейронов моллюска под влиянием лидокаина и соединения s-1

It was shown that the local anesthetics lidocaine and new compound with the local anesthetising effect S-1 in 0,1, 1, 10, 100 и 1000 µM concentrations decreased sodium, calcium and potassium ionic currents in a concentration-dependent manner. An amplitude of potassium slow currents increased by 5-10% as compared to control under the influence of lidocaine in low concentrations (from 0,1 to 10 µM), whereas it decreased in higher concentrations. In the concentration 1000 µM an amplitude of all ionic currents decreased approximately by 50%, thus selectivity of the effect of the studied compounds on ionic channels was not found. The membranetropic effect of lidocaine and S-1 on neurons might also be carried out through the influence on nonspecific membrane conductivity, potential of membrane surface charge near ionic channels, kinetics of activation or inactivation of ionic currents. The compound S-1 inhibited the sodium, calcium (by 20%) and potassium ionic currents (by 10%) in a larger degree than lidocaine and had a 2-3 times more long-term aftereffect, i. e. was more bound to ionic channels.