Recombinant Shiga Toxin B Subunit Can Induce Neutralizing Immunoglobulin Y Antibody

Paola Neri,a Shunji Tokoro,a Tsuyoshi Sugiyama,a Kouji Umeda,b, Takeshi Shimizu,c Takao Tsuji,d Yoshikatsu Kodama,b, and Hiroshi Mori*,a a Microbiology, Department of Biopharmaceutical Sciences, Gifu Pharmaceutical University; 1–25–4 Daigaku-nishi, Gifu 501–1196, Japan: b Immunology Research Institute, GHEN Corporation; 839–1 Sano, Gifu 501–1101, Japan: c Department of Molecular Infectiology, Graduate School of Medicine, Chiba University; 1–8–1 Inohana, Chiba 260–8670, Japan: and d Department of Microbiology, School of Medicine, Fujita Health University; Toyoake, Aichi 470–1192, Japan. Received December 29, 2011; accepted February 29, 2012; published online March 23, 2012