The integrative analysis of DNA methylation and mRNA expression profiles confirmed the role of selenocompound metabolism pathway in Kashin-Beck disease.

Ping Li,Yujie Ning,Weizhuo Wang,Xiong Guo,Blandine Poulet,Xi Wang,Yan Wen,Jing Han,Jingcan Hao,Xiao Liang,Li Liu,Yanan Du,Bolun Cheng,Shiqiang Cheng,Lu Zhang,Mei Ma,Xin Qi,Chujun Liang,Cuiyan Wu,Sen Wang,Hongmou Zhao,Guanghui Zhao,Mary B. Goldring,Feng Zhang,Peng Xu

The integrative analysis of DNA methylation and mRNA expression profiles confirmed the role of selenocompound metabolism pathway in Kashin-Beck disease.

2020

Kashin-Beck disease (KBD) is an endemic chronic osteochondropathy. The etiology of KBD remains unknown. In this study, we conducted an integrative analysis of genome-wide DNA methylation and mRNA e...

Keywords:

Biology
Polymerase chain reaction
TGFBI
KEGG
Molecular biology
DNA methylation
Kashin–Beck disease
Osteochondropathy
Gene
Candidate gene

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