Relationship Between Sunitinib Pharmacokinetics and Administration Time: Preclinical and Clinical Evidence

Jacqueline S. L. Kloth,Lisette Binkhorst,Annelieke S. de Wit,Peter de Bruijn,Paul Hamberg,Mei H. Lam,Herman Burger,Inês Chaves,Erik A.C. Wiemer,Gijsbertus T. J. van der Horst,Ron H.J. Mathijssen

Relationship Between Sunitinib Pharmacokinetics and Administration Time: Preclinical and Clinical Evidence

2015

Jacqueline S. L. Kloth
Lisette Binkhorst
Annelieke S. de Wit
Peter de Bruijn
Paul Hamberg
Mei H. Lam
Herman Burger
Inês Chaves
Erik A.C. Wiemer
Gijsbertus T. J. van der Horst
Ron H.J. Mathijssen

Background and Objective Circadian rhythms may influence the pharmacokinetics of drugs. This study aimed to elucidate whether the pharmacokinetics of the orally administered drug sunitinib are subject to circadian variation.

Keywords:

Prospective cohort study
Drug
Pharmacology
Crossover study
Circadian rhythm
Sunitinib
Pharmacokinetics
Medicine
Pharmacotherapy
administration time
clinical evidence

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