Warfarin Use Was Not Associated With Changes in Bone Mineral Density in the Population-Based Canadian Multicentre Osteoporosis Study (CaMos)

s / Can J Diabetes 39 (2015) 529e547 544 clinical and electrophysiological criteria. CNFL was determined by manual (CNFLManual, reference standard) and automated (CNFLAuto) protocols, and results were compared for correlation and agreement using Spearman coefficients and the method of Bland and Altman. Associations with neuropathy severity were evaluated by analysis-of-variance. Results: Participants demonstrated broad variability in clinical characteristics associated with neuropathy. The mean age, diabetes duration and HbA1C was 53.1 17.6 years, 15.9 12.6 years, and 7.4 1.6%, respectively, and 218 (47%) individuals had neuropathy. Mean CNFLManual was 15.1 4.9 mm/mm2, and mean CNFLAuto was 10.5 3.71 mm/mm2 (CNFLAuto underestimation bias, 4.58 2.65 mm/mm2 corresponding to 36.6 22.1%). Bias was similar across healthy volunteer, type 1, and type 2 diabetes subgroups. Levels of CNFLAuto and CNFLManual were both associated with neuropathy severity (ANOVA p<0.0001 for each comparison). Conclusions: Although CNFLAuto substantially underestimated CNFLManual, its bias was non-differential between diverse patient groups and its relationship with neuropathy severity was preserved. Determination of diagnostic thresholds specific to CNFLAuto should be pursued in diagnostic studies of diabetic neuropathy. 054-2015. CLINICAL CARE Validity of an Automated Protocol of In Vivo Corneal Confocal Microscopy for Diabetic Sensorimotor Polyneuropathy Detection in Type 1 Diabetes DANIEL SCARR, ILIA OSTROVSKI, LEIF ERIK LOVBLOM, TONG WU, ELISE M. HALPERN, MYLAN NGO, EDUARDO NG, ANDREJ ORSZAG, VERA BRILy, BRUCE A. PERKINS*y