Abstract 9330: In-stent Restenotic Tissue with a Microchannel in Patients with Diabetes: Insights from Coronary Optical Coherence Tomography Image Analysis

Introduction Coronary optical coherence tomography (OCT) allows the detection of subtle differences in patients with coronary artery disease. To date, OCT can virtually depict the various histological findings that occur at in-stent restenotic tissue. The present study investigated the clinical implications of microchannels located in in-stent restenotic sites. Methods We examined 48 consecutive in-stent restenotic (stenosis area, >50%) coronary artery lesions from 44 patients who underwent coronary OCT. OCT images were obtained with a time-domain OCT imaging system. The images were acquired during automatic-pull back (1 mm/s; 20 frames/s). A microchannel was defined as the low signal cavity with a diameter of 50-150 µm (Figure; white arrows) and was evaluated by 2 independent analysts. A third analyst provided the final decision when there was a discrepancy between the first and second analysts. Diabetes was diagnosed in accordance with the guidelines of the Japanese Diabetes Society. Results In total, 1...