Characterization of a 82Rb generator for positron emission tomography

Characteristics of the developed 82Rb medical generator intended for the production of Rubidium Chloride, 82Rb from Generator radiopharmaceutical for positron emission tomography (PET) are examined. The results of laboratory tests and clinical trials are presented. The influence of thermal sterilization on the ionexchange characteristics of the sorbent based on hydrous tin(IV) oxide is studied. The possibility of radiation “self-sterilization” of the generator column and of the maintenance of aseptic conditions in it throughout the generator operation life is assessed. In the course of operation of one generator, it is possible to obtain up to 19 L of a sterile and apyrogenic solution of the radiopharmaceutical with permissible content of radioactive and stable impurities. The efficiency of the 82Rb elution from the sorbent at different eluent flow rates is determined. The efficiency of using the generator in PET investigations in cardiology and oncology is demonstrated.