As bile acid sequestrant crosslinked polyvinylamine, polyallylamine, and ethyleneimine

The present invention provides for the binding and removal of bile salts, amines and amides polymer crosslinked effective from the gastrointestinal tract. The bile acid binder may be a polymer or a pharmaceutical composition administered to a subject to treat various conditions, including hypercholesterolemia, diabetes, pruritus, irritable bowel syndrome - diarrhea (IBS-D), a bile acid absorption and poor.