Synthesis, Characterisation and Antimicrobial Studies of 2-(Morpholin-4-yl(Pyridine-3-yl)Methyl) Hydrazinecarboxamide and its Transition Metal Complexes

II complexes of Mannich base, as ligand, was prepared by condensation of aqueous semicarbazide, morpholine and pyridine-3-carboxaldehyde. The structure of the newly synthesized Mannich base was investigated by UV-Vis, IR, 1 H-NMR, 13 C-NMR, molar conductance and magnetic susceptibility studies. The antimicrobial activities of the ligand and metals complexes have been screened in vitro against the organisms E.faecalis, Proteus mirabilis, Bacillus cereus, E.aerogens, ESBL E.coli, ESBL K.pneumoniae, by disc diffusion and well diffusion techniques. It is observed that the coordination of metal ions has pronounced effect on the microbial activities of the ligand. The metal complexes have higher antimicrobial effect than the free ligand. ABSTRACT