Preparation and characterization of Fe doped n-hydroxyapatite for biomedical application

Abstract Natural and synthetic biomaterials are often used in clinical utilization to assist, strengthen and to restore impaired tissue or biological functions. Iron doped bioactive nano-crystalline hydroxyapatite (Fe doped n-HAp) powder with different concentrations of Fe was successfully synthesized by the reflux method. The crystallinity of the samples was confirmed by powder XRD analysis and in 0.2 M Fe doping, the smallest crystalline size of 3.2 nm was obtained. SEM results indicate that higher concentration of Fe content has a considerable impact on the morphology of n-HAp material. The functional group assignments and the iron dopant incorporation has been analyzed and confirmed through FTIR and Raman results. The antibacterial activity test of Fe doped n-HAp mixed with amoxicillin antibiotic displays good inhibition to the bacterial strains.