Idiopathic anaphylaxis yardstick: Practical recommendations for clinical practice

Abstract Anaphylaxis is considered idiopathic when there is no known trigger. The signs and symptoms of idiopathic anaphylaxis (IA) are identical to those of anaphylaxis due to a known cause and can include cutaneous, circulatory, respiratory, gastrointestinal, and neurologic symptoms. IA can be a frustrating disease for patients and healthcare providers. Episodes are unpredictable and differential diagnosis is challenging. Current anaphylaxis guidelines have little specific guidance regarding differential diagnosis and long-term management of IA. Therefore, the objective of the Idiopathic Anaphylaxis Yardstick is to use published data and the authors’ combined clinical experience to provide practical recommendations for the diagnosis and management of patients with IA.