Amoitone derivative long-circulation nanometer lipid carrier and preparation method thereof

The invention discloses an amoitone derivative long-circulation nanometer lipid carrier which comprises the following main components: crude medicine Amoitone B, polyoxyethylene glycol bisstearate, solid lipid material, liquid lipid material, fat-soluble emulsifier, water-soluble emulsifier and injection water. The preparation method of the amoitone derivative long-circulation nanometer lipid carrier is an emulsion evaporating-low temperature curing method. The amoitone derivative long-circulation nanometer lipid carrier prepared by the preparation method has a slow release function in the body, is capable of effectively prolonging the in-vivo retention time of the medicine and improving the bioavailability of the medicine, has higher encapsulation efficiency and medicine carrying amount and a grain size of about 200nm, and can be passively targeted to a liver tissue, so that the toxic and side effects of the Amoitone B are lowered. Moreover, the amoitone derivative long-circulation nanometer lipid carrier is good in biocompatibility, easy to degrade, good in stability and capable of improving body tolerance and patient compliance.