(R)-3-(N-Methylpyrrolidin-2-ylmethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives as high affinity h5-HT1B/1D ligands

Abstract A series of ( R )-3-( N -methylpyrrolidin-2-ylmethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives ( 2 ) have been prepared using parallel synthesis, and their structure–activity relationship studied. High affinity human 5-HT 1B/1D (h5-HT 1B/1D ) ligands have been identified.