The analysis for the relationship between the CD4~+T cell and HIV infection in gastric mucosa from patients with acquired immune deficiency syndrome

Objective To investigate the relationship between CD4+T cell depletion and restoration and HIV infection in gastric mucosa from patients with AIDS.Methods 35 AIDS patients were enrolled.In situ hybridization (ISH) test and immunohistochemistry (IHC) method were performed to detect HIV infection in CD4+ T cells in gastric mucosal tissues of AIDS patients,and similar detection was performed in peripheral blood mononuclear cells (PBMC).Results ①Even if patients had received HAART for 1～4 years,amount of CD4+ T cells in MMC were lower than that of control group[(37.44± 18.00]% vs (50.35±3.41)%] (P 0.01);However,amount of CD4+T cells in PBMC were similar with that of control group [(42.70±10.66)% vs (51.00±6.60)%] (P 0.05).②The HIV infection of CD4+T cells in MMC between AIDS patients who had not received HAART and AIDS patients with HAART for less than one year was not obviously different[(2.76±1.92)% vs (1.88±1.56)%] (P 0.05).CD4+T cells in the patients who had received HAART for 1～4 years were more depleted (0.54±0.49)%;Among 3 AIDS groups,we found the HIV infection of CD4+T cells in PBMC was different [(19.44±8.17)% vs (9.76±6.98)% vs (4.95±8.26)%,respectively] (P 0.05).Conclusions It may indicate that CD4+T cells restoration was delayed during HAART compared with peripheral blood,HIV infection in CD4+T cell may not produce a marked effect in the depletion and delayed restoration of CD4+T cell in gastric mucosa from patients with AIDS.