Abstract 15412: Novel Treatment of Hypertension by Specifically Targeting E2F for the Restoration of Endothelial Dihydrofolate Reductase and eNOS Function Under Oxidative Stress

We have previously shown that hydrogen peroxide (H2O2) downregulates the tetrahydrobiopterin (H4B) salvage enzyme dihydrofolate reductase (DHFR) to result in eNOS uncoupling and elevated blood pres...