A versatile one-pot synthesis of novel substituted pyrazoles, isoxazoles and their antimicrobial activity

An efficient synthesis of novel, substituted pyrazoles and isoxazoles are described. The title compounds (2a-c), (3a-c) and (4a-c) are obtained by one pot acid catalyzed cyclocondensation of Ethylacetoacetate with various 5-substituted 2-phenylindole-3-corboxaldehydeswith hydrazinehydrate, phenylhydrazine and hydroxylaminehydrochloride respectively in presence of dimethyleformamide in good yields. Synthesized compounds have been characterized on the basis of their physical, spectral and analytical data. Compounds have also been subjected to antibacterial screening against S. aureus, and B. subtilis, and antifungal screening against A. niger and A. flavous.