Method for combining Fingolimod intermediate
2013
The present invention provides a method of synthesizing fingolimod intermediate, the method comprising: a, compound 1 and 2 occur Wittig reaction to form compound 3; B, compound 3 in the presence of a catalyst Pd / C, hydrogenation reaction occurs to give compound 4; C, compound 4 with acid pinacol ester, the BPO and t-BuONO give compound 5; D, compound 5 and iodides 6 occurs Suzuki reaction of compound 7; E, compound 7 at a Pd / C catalyst , a hydrogenation reaction to give compound 8 occurs. Scheme present invention, a brief, simple operation, low cost, high yield, easy industrial production.
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