Total synthesis of (+)-cladospolide D

Abstract The asymmetric total synthesis of cladospolide D, a natural 12-membered macrolide antibiotic, has been accomplished in 12-steps. Sharpless asymmetric dihydroxylation, Grubb’s cross metathesis, and Shiina lactonization have been employed as the key reactions for the installation of the desired stereocenter and the construction of the macrolactone framework.