In vitro adsorption of mepyramine maleate onto some adsorbents and antacids

Abstract The adsorption of mepyramine maleate on bentonite, charcoal, magnesium oxide, magnesium carbonate, magnesium trisilicate, bismuth carbonate and kaolin, was investigated. Maximum adsorption was found with charcoal followed by bentonite while kaolin and bismuth carbonate showed minimum adsorption. The results also showed that as the weight of the adsorbent increases the amount of drug adsorbed per gram decreased. Behaviour of charcoal and bismuth carbonate followed Langmuir and Freundlich isotherms. The present study also revealed that firstly, it is contraindicated to coadministrate mepyramine maleate with the tested adsorbents and antacids; secondly, cetrimide can be added to formulated antidotes for improving their adsorption efficiency.