Reduced Sampling Schedules for Calculation of an Insulin Sensitivity Index from the Liquid Meal Tolerance Test

th , 2015 ABSTRACT Background: The objective of this study was to evaluate the performance of the Matsuda index of insulin sensitivity (MISI) calculated using reduced sampling schedules. Methods: Relationships between MISI values from a Liquid Meal Tolerance Test (LMTT) and insulin sensitivity (S I ) derived from an intravenous glucose tolerance test were assessed in 24 overweight/obese subjects (67% women) without diabetes. Results: Significant correlations were found between S I and 1) MISI calculated from 0, 30, 60, 90, and 120 min (r=0.776, p <0.0001); 2) MISI calculated from 0, 60, and 120 min (r=0.815, p <0.0001); and 3) MISI calculated from and 0 and 120 min (r=0.848, p <0.0001). Conclusion: MISI from LMTTs calculated using reduced sampling schedules (0, 60, 120 min or 0, 120 min) may be useful, lower cost options for assessment of insulin sensitivity in popula- tion studies and large clinical trials.