Synthesis and antimutagenic effects of selena-morpholine hydrate

The synthesis of selenamorpholine hydrate was described and its antimutagenic effects were investigated by the Ames tests. The results indicated that the mutation induced by the indirect mutagen 2-AF was inhibited obviously by selenamorpholine hydrate at the dosage of Se 0.16∼100 μg/dish for 35.8%∼53.7% (TA97) and the mutation induced by direct mutagen Dexon was inhibited for 6.2%∼30.0% (TA97) and 2.3% ∼34.1% (TA100). The mutagenesis of the indirect mutagen cyclophosphamide was suppressed for 5.4%∼ 16.1% by selenamorpholine hydrate at the dosage of Se 0.16∼100 μg/dish.