Synthesis and antimutagenic effects of selena-morpholine hydrate
2000
The synthesis of selenamorpholine hydrate was described and its antimutagenic effects were investigated by the Ames tests. The results indicated that the mutation induced by the indirect mutagen 2-AF was inhibited obviously by selenamorpholine hydrate at the dosage of Se 0.16∼100 μg/dish for 35.8%∼53.7% (TA97) and the mutation induced by direct mutagen Dexon was inhibited for 6.2%∼30.0% (TA97) and 2.3% ∼34.1% (TA100). The mutagenesis of the indirect mutagen cyclophosphamide was suppressed for 5.4%∼ 16.1% by selenamorpholine hydrate at the dosage of Se 0.16∼100 μg/dish.
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