Quad-contrast Imaging: Simultaneous Acquisition of Four Contrast-weighted Images (PD-weighted, T2-weighted, PD-FLAIR and T2-FLAIR images) with Synthetic T1-weighted Image, T1-and T2-Maps.

Magnetic resonance imaging (MRI) can provide multiple contrast-weighted images using different pulse sequences and protocols. However, a long acquisition time of the images is a major challenge. To address this limitation, a new pulse sequence referred to as quad-contrast imaging is presented. The quad-contrast sequence enables the simultaneous acquisition of four contrast-weighted images (proton density (PD)-weighted, T2-weighted, PD-fluid attenuated inversion recovery (FLAIR), and T2-FLAIR), and the synthesis of T1-weighted images and T1-and T2-maps in a single scan. The scan time is less than 6 min and is further reduced to 2 min 50 s using a deep learning-based parallel imaging reconstruction. The natively acquired quad contrasts demonstrate high quality images, comparable to those from the conventional scans. The deep learning-based reconstruction successfully reconstructed highly accelerated data (acceleration factor 6), reporting smaller normalized root mean squared errors (NRMSEs) and higher structural similarities (SSIMs) than those from conventional generalized autocalibrating partially parallel acquisitions (GRAPPA)-reconstruction (mean NRMSE of 4.36% vs. 10.54% and mean SSIM of 0.990 vs. 0.953). In particular, the FLAIR contrast is natively acquired and does not suffer from lesion-like artifacts at the boundary of tissue and cerebrospinal fluid, differentiating the proposed method from synthetic imaging methods. The quad-contrast imaging method may have the potentials to be used in a clinical routine as a rapid diagnostic tool.