Efficacy and adverse reactions of chronic hepatitis C treated with peg-interferon alpha-2a and ribavirin

Objective:To observe the efficacy and adverse reactions of managing chronic hepatitis C with peg-interferon alpha-2a and ribavirin.Methods:The virological response of 63 patients with hepatitis C virus(HCV) infection after anti-HCV management were retrospectively analyzed.All patients were given peg-IFN alpha-2a and ribavirin for 48 weeks.HCV RNA was tested before treatment,at 12 and 24 weeks post management,end of treatment,24 and 48 weeks after treatment stopped.The side effects were also observed.Results:The rapid virological response was 58.7%(37/63),the early virological response,the end-of-treatment virological response,the sustained virological response of 24 weeks after treatment stopped and 48 weeks when treatment stopped were 68.2%(43/63),73%(46/63),65%(41/63).There were 5 patients who stopped peg-interferon alpha-2a because of the side effects.The main side effects was flu-like symptoms,gastrointestinal symptoms,blood routine disorders,psychiatric symptoms and thyroid diseases.Conclusion:PEG-IFN alpha-2a in combination with ribavirin can effectively and safely treat patients with chronic hepatitis C.Earlyer discover the adverse reactions and ensure patients' whole course of treatment.