Impact of overweight on glucose homeostasis in MODY2 and MODY3.

Maturity-onset diabetes of the young (MODY) is the most common type of monogenic diabetes, as it accounts for approximately 1-2% of all cases of diabetes [1]. MODY2 is caused by mutations in the gene encoding glucokinase (GCK), whereas MODY3 is due to mutations in the hepatocyte nuclear factor 1A (HNF1A) gene. Obesity has become prevalent and the aim of this study was to investigate to what extent BMI and age affected fasting serum glucose and glycosylated hemoglobin (HbA1c) in female and male MODY2 and MODY3 probands.