Lack of Association Between Pretreatment Neurology Consultation and Subsequent Protocol Deviation in Tissue Plasminogen Activator-Treated Patients With Stroke

Background and Purpose—We evaluated the hypothesis that consultation with neurology would be associated with fewer protocol deviations in tissue plasminogen activator-treated patients with stroke. Methods—A retrospective analysis of consecutive tissue plasminogen activator-treated patients with acute patients was performed. Using χ2 tests, the proportion of patients with a protocol deviation was calculated and compared between those with evidence of a neurology consultation and those without. Logistic regression was then used to determine the OR for protocol deviation at the same time as controlling for clinical presentation covariates. Results—Two hundred seventy-three subjects were included. Protocol deviation rates did not significantly differ between those with (44%) and those without (41%) a consultation. The adjusted OR for deviation comparing any consultation versus nonconsultation was 1.25 (95% CI: 0.58 to 2.68). There was no statistically significant difference between symptomatic intracranial he...