The humanistic burden of advanced non-small cell lung cancer on patients and their caregivers.

220Background: A diagnosis of advanced non-small cell lung cancer (aNSCLC) presents significant physical, emotional and financial challenges for patients and their caregivers. This study provides insight into the humanistic burden on patients and their caregivers, as the disease progresses. Methods: Data were taken from a chart review and a cross-sectional study of a NSCLC patients and caregivers in France, Germany and Italy. Physicians provided data on patients’ age, sex, stage, line of therapy and ECOG (Eastern Cooperative Oncology Group) performance status (PS). The patient survey assessed the patients’ health state (EQ-5D), impact on work/activities (WPAI) and on quality of life (EORTC QLQ-C30). The caregiver survey included the WPAI and Zarit Burden Interview (ZBI). Patient and caregiver outcomes were stratified by the patients’ ECOG PS from 0 to 4 (best to worst status). Statistical significance was assessed using Kruskal-Wallis tests. Results: 1,030 patients completed the survey (mean (SD) age: 64....