177 ‘Notching' of the Right Ventricular Outflow Tract Doppler Profile (DopplerRVOT) Is a Highly Sensitive and Specific Predictor of Pulmonary Vascular Disease among Patients with Systemic Sclerosis

ples until delivery. Patients had BOS grade 2 or 1 with risk factors for rapid progression. Patients with 3 infective exacerbations in the preceding year or a history of CMV pneumonitis were excluded. 2*10 cells/kg were delivered via a large peripheral vein twice weekly for two weeks. The primary outcome measure was safety. Results: 4 patients (1 female, 2 IPF, 1 CF, 1 COPD, median age 52 (28-62), 1 BOS2, 3 BOS3) were treated. MSC treatment was well tolerated with all patients receiving the full dosing schedule. No procedure-related serious adverse events occurred and few adverse events were recorded, with halitosis (due to DMSO) being the most common. There was no evidence of worsening fibrosis. 1 patient experienced a progressive downward trajectory of FEV1 unaltered by MSC treatment and died 152 days post-infusion. 3 patients experienced stabilisation of lung function.