Carboxamide compounds and methods of use thereof

A compound having the structural formula Formula ** ** or a pharmaceutically acceptable salt or N-oxide thereof, wherein R1 is H, - (C1-C4 alkyl, C2-C4 or C2-C4), -C (O) - (C1-C4 alkyl, C2-C4 or C2-C4) or -C (O) O- (C1-C4 alkyl, C2-C4 or C2-C4 alkynyl); R2 is - (yl azetidin-3-optionally substituted), - (piperidin-4-yl optionally substituted), - (yl pyrrolidin-3-optionally substituted) or - (yl azepan-4-optionally substituted), each substituted in 1 position with - (C0-C3 alkyl, C2-C3 alkenyl, or C2-C3) -Ar, - (C0-C3 alkyl, C2-C3 alkenyl, or C2-C3) Het, -C (O ) -O (C0-C6 alkyl, C2-C6, or C2-C6 alkynyl), -C (O) Het, -C (O) -Ar, -S (O) 2-Het, -S (O ) 2-Ar or -S (O) 2 -O (C0-C6 alkyl, C2-C6, or C2-C6); each R3 is independently selected from - (C1-C6 alkyl, C2-C6, or C2-C6 alkynyl), - (C1-C6), - (alkyl C0-C6 alkyl, C2-C6, or C2-C6 ) -L-R7, - (alkyl C0-C6 alkyl, C2-C6, or C2-C6) -NR8R9, - (alkyl C0-C6 alkyl, C2-C6, or C2-C6) -OR10, - ( C0-C6 alkyl, C2-C6, or C2-C6) -C (O) R10, - (C0-C6 alkyl, C2-C6, or C2-C6) -S (O) 0-2R10, -halogen, -NO2 and -CN; w is 0, 1, 2 or 3; each R4 is independently selected from - (C1-C6 alkyl, C2-C6, or C2-C6 alkynyl), - (C1-C6), - (alkyl C0-C6 alkyl, C2-C6, or C2-C6 ) -L-R7, - (alkyl C0-C6 alkyl, C2-C6, or C2-C6) -NR8R9, - (alkyl C0-C6 alkyl, C2-C6, or C2-C6) -OR10, - ( C0-C6 alkyl, C2-C6, or C2-C6) -C (O) R10, - (C0-C6 alkyl, C2-C6, or C2-C6) -S (O) 0-2R10, -halogen, -NO2 and -CN 25, and two R4 on the same carbon optionally combine to form oxo; x is 0, 1, 2, 3 or 4; p is 0, 1, 2, 3 or 4; q is 2, 3 or 4; the sum of p and q is 2, 3, 4, 5 or 6; Q is -S (O) 2-, L or - (alkyl C0-C3, C2-C3 alkenyl, or C2-C3) -, wherein each carbon of - (C0-C3, C2-C3, or C2-C3) - is optionally and independently substituted with one or two R16; the ring system denoted by "A" is heteroaryl or aryl; each R5 is independently selected from - (C1-C6 alkyl, C2-C6, or C2-C6 alkynyl), - (C1-C6), - (alkyl C0-C6 alkyl, C2-C6, or C2-C6 ) -Ar, - (alkyl C0-C6 alkyl, C2-C6, or C2-C6) -Het, - (alkyl C0-C6 alkyl, C2-C6, or C2-C6) -Cak, - (alkyl C0 C6, C2-C6 alkenyl or C2-C6) -Hca, - (alkyl C0-C6 alkyl, C2-C6, or C2-C6) -L-R7, - (alkyl C0-C6 alkyl, C2-C6 or C2-C6) -NR8R9, - (alkyl C0-C6 alkyl, C2-C6, or C2-C6) -OR10, - (alkyl C0-C6 alkyl, C2-C6, or C2-C6 alkynyl) - C (O) R10, - (C0-C6 alkyl, C2-C6, or C2-C6) -S (O) 0-2R10, -halogen, -NO2 and -CN, and when y is 1, -C (O) Hca in which the Hca contains a ring nitrogen atom through which binds to the -C (O) -; y is 0, 1, 2, 3 or 4;