A short, convergent synthesis of two chiral antiviral agents, (+) carbocyclic 2′-deoxy-5-[(E)-2-bromovinyl] uridine and (+) carbocyclic 2′-deoxyGuanosine

Abstract Stereoselective microbial reduction of ketone 2 gave the alcohol 5 which was coupled under Mitsunobu conditions with the protected pyrimidine 7 and purine 10 to give on deprotection the chiral antiviral nucleosides (+) carbocyclic 2′-deoxy-5-[(E)-2bromovinyll uridine 9 and (+) carbocyclic 2′-deoxyguanosine 12 .