A TRIAL OF CT1341

SUMMARY CT1341 is a mixture of two steroids which on intravenous injection produces clinical anaesthesia in one arm-brain circulation time. It was used as the sole anaesthetic agent (in single or repeated dosage) in 109 patients undergoing a variety of procedures. In a further 44 patients CT1341 was supplemented with nitrous oxide and oxygen. The dosage of CT1341 employed for induction ranged from 0.04 to 0.12 ml/kg. The duration of anaesthesia was related to dosage; there was a variable amount of clinical analgesia. The pattern of recovery differed somewhat from that seen with barbiturates and eugenol-type intravenous anaesthetics. CT1341 usually produced a rise in pulse rate and respiration rate and some fall in blood pressure. Respiratory and muscular irritability were seen and appeared to be related to dosage. The incidence of nausea, vomiting and local irritation was very low. This new anaesthetic merits further study, particularly as an induction agent for general anaesthesia.