Лазерная терапия в коррекции функционального статуса печени при тяжелой механической желтухе панкреатогенного происхождения

Purpose: To study the effectiveness of laser therapy in the correction of hepatic encephalopathy in severe mechanical jaundice of pancreatogenic origin. Material and methods. 30 patients with severe mechanical jaundice of pancreatogenic origin were taken into the study and divided into two groups: Group 1 – 15 patients who had standard therapy; Group 2 – 15 patients who had standard therapy plus laser therapy (transcutaneous quantum irradiation in the projection of the cubital vein for 15 minutes and in the projection of common carotid and vertebral arteries for 5 minutes on each side). 10 healthy individuals were taken as controls. For laser therapy, laser device “Matrix” with KLOS head was used (wavelength 635 nm, power 2 mW; registration certificate No. FSR 2007/00589, certificate of conformity ROSS RU.AV35.D00082). Assessment of microcirculation (microcirculation index – MI, index of microcirculation efficiency – IME and bypass rate – BR) was made using Doppler flowmeter (Ltd “Lazma”, Russia) findings. Liver functional status was assessed by the activity of alanine aminotransferase (ALT) and by the level of total bilirubin in blood plasma. Results. As it has been found out, in case of obstructive jaundice of pancreatogenic origin, liver damage is associated with significant microcirculatory disorders which are recorded on the first 8 days since therapy starts. If to include subvascular laser irradiation of blood into the complex treatment, one can have a relatively rapid restoration of liver functional status what can be explained by the ability of the discussed laser therapy technique to correct microcirculatory shifts.