Comparison study on the efficacy of bronchiolitis between different dosage of nebulised Budesonide Suspension for Inhalation

Objective To evaluate the clinical feature of pediatric patients with bronchiolitis,and compare their treatment response between different dosage of nebulised Budesonide Suspension for Inhalation.Methods The data of the children diagnosed and administrated between 2011.1-2011.5 were collected and analyzed by soft ware SPSS 19.0.The patients were randomly divided into 0.5mg group(nebulised Budesonide Suspension for Inhalation 0.5mg once)and 1mg group(nebulised Budesonide Suspension for Inhalation 1mg once).The clinical score,respiratory frequency,oxygen saturation,length of stay,the cost were evaluated.Results 30 minutes after the treatment,The clinical score in 1mg group(6.28±1.16)was statistically lower than that(6.91±1.03)in the 0.5mg group(P=0.007),the respiratory frequency in 1mg group(55.7±7.1)was statistically lower than that(60.23±6.2)in the 0.5mg group(P=0.003),the oxygen saturation in 1mg group(96.7±2.5%)was statistically higher than that(94.3±1.8%)in the 0.5mg group(P0.001).60 minutes after the treat,The clinical score in 1mg group(5.14±1.58)was statistically lower than that(6.25±1.37)in the 0.5mg group(P0.001),the respiratory frequency in 1mg group(51.5±7.3)was statistically lower than that(55.3±6.4)in the 0.5mg group(P=0.016),the oxygen saturation in 1mg group(97.2±2.6%)was statistically higher than that(95.6±2.3%)in the 0.5mg group(P=0.004)the length of stay in 1mg group(6.42±1.89) was statistically shorter than that(8.71±2.53) in the 0.5mg group(P0.001),the cost of hospitalization in 1mg group(2142±164$)was statistical cheaper than that(2573±189$)in 0.5mg group(P0.001).Conclusion The treatment response of the patients with bronchiolitis in 1mg group are better than that in 0.5mg group,These include faster changing in clinical score,respiratory frequency,oxygen saturation;shorter hospital day and less cost.