Perbedaan Efektifitas Anestetikum antara Zoletil-Acepromacin dan Ketamin-Acepromacin pada Tikus Putih (Rattus Novergicus)

2015 
The aim of this research was to find out the effects of zoletil-acepromacin and ketamin-acepromacin as general anaesthetics on heartbeat, respiratory rate, body temperature, onset of action and duration of action in rat. This research used as much as 27 rats and were devided into 3 groups of treatments. P0 as control group was injected with aquabidest by intraperitoneal injection. P1 was injected with atropine sulphate (0,05 mg/kg BW) sc for premedication and ketamin (75 mg/kg BW)-acepromacin (2,5 mg/kg BW) by ip as anaesthetic. P2 was injected with atropine sulphate (0,05 mg/kg BW) sc for premedication and zoletil (50 mg/kg BW)-acepromazin (2,5 mg/kg BW) by intraperitonela as anaesthetic. The results showed that the combination of ketamin-acepromacin and zoletil-acepromacin depress the heart beat and respiratory rate. The body temperature in P2 were recorded lower than in P1. However,the onset of action and duration were longer in P1 than in P2.
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