Субпопуляции Т-регуляторных клеток при бронхиальной астме и гетерогенных фенотипах хронической обструктивной болезни легких Кириллова Н.А., Деев И.А., Кремер Е.Э., Огородова Л.М., Черногорюк Г.Э. T-regulatory cells subpopulation in bronchial asthma and heterogeneous phenotypes of chronic obstructive pulmonary disease

Aim of the study was to investigate the levels of individual subpopulations of T-regulatory (T-reg) cells in patients with different phenotypes of chronic obstructive pulmonary disease (COPD) with moderate bronchial asthma and healthy volunteers. COPD was asso- ciated with increased level of natural (CD4 + CD25 high ) T-cells, while emphysematous phenotype of disease was associated with the highest pool of natural CD4 + CD25 high . Bronchial asthma was associated with low levels of inducible (CD4 + FoxP3 + ) T-reg.