Regulating effect of lncRNA on aerobic glycolysis in tumor cells

Long noncoding RNA (lncRNA) is a kind of RNA with a length greater than 200 nucleotides and lacks protein-coding function. Varieties of lncRNAs have been found to play major roles in the aerobic glycolysis of tumor cells, such as lncRNA-p21, H19, prostate specific transcript 1 (PGCEM1) and so on. In tumor cells, lncRNA can directly regulate the rate-limiting enzyme in the glycolytic pathway, also can indirectly regulate the glycolysis by hypoxia inducible factor-1α (HIF-1α) or proto-oncogene c-myc. Further study on the mechanism of lncRNA regulating tumor cell glycolysis is expected to open up new ideas for the diagnosis and treatment of tumor diseases. Key words: Neoplasms; Glycolysis; RNA, long noncoding